Applications of Synapsis AI in healthcare

Dyania’s Synapsis AI is a holistic end-to-end system, commercially viable for enterprise use in oncology, cardiology, autoimmune conditions, and other disease areas with significant population impact. Synapsis AI delivers precision, speed, and scalability across various clinical applications:

Patient Finder™

Identify and pre-screen patients daily for clinical trial eligibility, accelerating recruitment and reducing timelines. Synapsis AI is a proprietary LLM (and end-to-end system) that continuously reads dynamically-changing patient EMRs to ensure you don’t miss potential participants.

  • Find more candidates, faster. (Over 15,000x faster, to be exact!)
  • Leverage Dyania’s intuitive app to query specific clinical questions, review EMR data at the individual level, and search for candidates by trial site to automatically identify eligible patients based on trial criteria.
Observational Studies

Uncover clinical characteristics for retrospective and prospective studies with unparalleled accuracy and at scale. Synapsis AI facilitates a deeper understanding of patient populations, fueling evidence-based research.

  • Dyania will partner with healthcare systems to deliver custom insights (such as cohort suggestions) from EMRs that help support ongoing observational and RWD research.
Study Feasibility

Leverage AI-driven insights to design trials that are efficient, effective, and aligned with real-world data. Dyania’s in-house clinical team will analyze trial criteria to provide organizations with insights on whether specific trial sites have enough patient populations to support a given study, allowing them to make data-driven decisions.

  • Custom reports, delivered to key internal stakeholders, can facilitate data-driven decision-making and expedite clinical trials.
Registries Reporting

Streamline registry population and reporting submissions. Synapsis AI extracts and organizes clinical characteristics, eliminating manual bottlenecks and improving data accuracy. Synapsis AI abstracts and organizes clinical characteristics into field responses, eliminating the manual effort while improving overall on accuracy of abstraction.

On average, health systems with ~500,000 patients spent >$5 M annually on staff performing manual chart abstraction. Medically-specialized personnel are understaffed globally and need every second of their time available to treat patients who need it most.

  • Save up to 50% of these costs by partnering with Dyania.
  • Identify custom, unique fields for reporting to national registries and use Dyania’s native audit tool to save time and money.
Evidence Guided Care Pathways

In a large health system with thousands of providers and millions of patients, we help health systems treat each patient individually at scale, where it would not be humanly possible. Synapsis AI takes numbers and data and turns that into opportunities to get patients the care they need. These can be patients who:

  • have with a specific set of medical needs
  • have presented with certain clinical characteristics for which they could benefit from a specific therapy
  • have presented with high risk factors for an undiagnosed condition
  • have potential to gain more appropriate care from a specialist if they could be referred at the right time when they need it.

Synapsis AI in action

Spotlight on Transthyretin Amyloidosis

Transthyretin amyloidosis (ATTR) is a rare and potentially life-threatening disease caused by the abnormal buildup of amyloid fibrils composed of transthyretin (TTR) protein. This condition primarily affects the heart muscle, resembling other diseases like congestive heart failure, making it notoriously difficult to diagnose.

~100,000 people in the U.S live with
ATTR-cardiomyopathy (ATTR-CM)

Only 1-2% of patients receive
a diagnosis

Despite an estimated 100,000 people in the U.S. living with ATTR-cardiomyopathy (ATTR-CM)—a subset of ATTR—only 1-2% of patients receive a diagnosis, highlighting a critical challenge in identifying and treating this underdiagnosed condition.

Accelerating Patient Identification with Synapsis AI

Dyania’s Patient Finder, powered by Synapsis AI, delivered game-changing results at Cleveland Clinic. For one phase 3, randomized, double-blind, placebo-controlled, multi-center ATTR-CM study sponsored by Alexion Pharmaceuticals, in just the first week after Patient Finder launch:

Cleveland Clinic

4 patients identified as “complete matches” for the trial

26 additional patients classified as “high partial matches,” all of whom qualified for the trial

97% of these patients had been missed during previous manual screening efforts

This success underscores the transformative potential of Synapsis AI to address critical gaps in patient identification, enabling healthcare systems and pharmaceutical companies to accelerate clinical trials and bring life-saving treatments to market faster.

Synapsis AI is paving the way for future excellence in healthcare

Emerging applications for Synapsis AI

  • Quality of Care & Therapeutic Gaps
    Synapsis AI can be leveraged to analyze clinical care pathways to assess adherence to or deviations from the Standard of Care, identifying opportunities to enhance patient treatment.
  • Medical Misdocumentation & Quality Assurance
    Synapsis AI can detect and flag errors or inconsistencies within clinical data, ensuring accuracy of EMRs, building trust with the public, and reducing the risk of costly mistakes.
  • Additional Disease Areas
    Dyania is dedicated to fundamental health research and is open to exploring R&D opportunities in additional disease areas including neurology and psychiatry, which are traditionally subjective fields.

How to bring Synapsis AI to your organization

Healthcare systems (HCS) can start deploying Synapsis AI as a commercially-scalable solution within a matter of months. The simple, streamlined process is a collaborative effort between Dyania physicians, Dyania engineers, and HCS leadership and IT professionals.

  • Business Agreement Dyania collaborates with HCS leadership to pinpoint specific nuances and use cases where chart review creates bottlenecks and set up the appropriate business and service agreements that ensure secure access to protected health information.
  • One-Time Deployment The Dyania team installs Synapsis AI within the healthcare system’s firewall. Secure access for all teams is ensured by VPN tunnel. Synapsis AI seamlessly integrates with EMR database structures and is mapped to the clinical relevance of each data type, ensuring minimal disruption to workflows.
  • Data Ingestion Synapsis AI ingests and structures vast quantities of EMR data, assessing with the clinical reasoning of a trained physician.
  • Insights Generation Our proprietary AI system analyzes patient records in real-time, extracting actionable insights tailored to your organizational needs.
  • Delivery Insights are delivered through intuitive, modular dashboards tailored to specific applications, enabling healthcare professionals to act quickly and confidently.
“

Through our work together with Dyania and the clinical leadership of Cleveland Clinic’s Heart, Vascular and Thoracic Institute and Cancer Institute, we are seeing early success with the technology in streamlining and accelerating the clinical trial recruitment process.

—Rohit Chandra, PhD
Cleveland Clinic’s Chief Digital Officer

Discover the Dyania Difference

Ready to revolutionize your approach to clinical research and patient care?

Let Synapsis AI bridge the gap between data and actionable insights. Contact us today to schedule a demo and learn how Synapsis AI can transform your healthcare operations. Contact us